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Synthesis of C-C bonded dimeric steroids by olefin metathesis
(Pergamon-Elsevier Science Ltd, 2009-05)
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and ...
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
(Taylor, 2017-01-08)
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the ...
DNA binding triggers tetramerization of the glucocorticoid receptor in live cells
(National Academy of Sciences, 2016-07)
Transcription factors dynamically bind to chromatin and are essential for the regulation of genes. Although a large percentage of these proteins appear to self-associate to form dimers or higher order oli gomers, t he ...
Orphan nuclear receptor NGFI-B forms dimers with nonclassical interface
(2007-08-01)
The orphan receptor nerve growth factor-induced B (NGFI-B) is a member of the nuclear receptor's subfamily 4A (Nr4a). NGFI-B was shown to be capable of binding both as a monomer to an extended half-site containing a single ...
Orphan nuclear receptor NGFI-B forms dimers with nonclassical interface
(2007-08-01)
The orphan receptor nerve growth factor-induced B (NGFI-B) is a member of the nuclear receptor's subfamily 4A (Nr4a). NGFI-B was shown to be capable of binding both as a monomer to an extended half-site containing a single ...
Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
(2017-03-01)
The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was ...
Steroid receptor coupling becomes nuclear
(Elsevier, 2012-06-22)
In this issue of Chemistry & Biology, Grossman et al. report a study on aldosterone-dependent nuclear translocation of the mineralocorticoid receptor (MR). They analyze the dependency of MR retrotransport, DNA-binding, and ...
Differential effects of TR ligands on hormone dissociation rates: Evidence for multiple ligand entry/exit pathways
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself This result was interpreted to mean that ...
Gastroprotective Effects Of Hydroethanolic Root Extract Of Arrabidaea Brachypoda: Evidences Of Cytoprotection And Isolation Of Unusual Glycosylated Polyphenols
(Pergamon-Elsevier Science LTDOxford, 2017)